I have no physical way of knowing whether my kidneys, adrenals, or thyroid glands are properly working because of this patch. I will say I sleep thru the night, and have almost 0 hot flashes during the night. I will tell you that overall, this product is working for me in a way I never expected it to-I feel calmer than I've ever felt. I would describe myself as always having some form of ADHD-i could never calm my thoughts-my brain was always racing. Now, my thoughts aren't scattered all over the place, and if that only takes $40/month, I'm using it. I also wear the patch for 4 days instead of 3, as I find no difference. And girls, put the bra on first, then place the patch on the upper left shoulder, so it doesn't get pulled off. Once you pull it off, it won't stick for 3+ days unless it's bandaid'd down.